Gastrointestinal nematode (GIN) infections significantly impact goat productivity and livelihoods of smallholder farmers in Nepal. This study assessed the efficacy of fenbendazole and ivermectin against GIN in goats from Siyari Rural Municipality, Rupandehi. Thirty goats with fecal egg counts (FEC) exceeding 300 eggs per gram were randomly assigned to fenbendazole-treated, ivermectin-treated, or untreated control groups. Fecal samples were collected on days 0, 7, 14, and 21 post-treatment and analyzed using the McMaster technique. FECRT results demonstrated high efficacy for fenbendazole (99.08%) and ivermectin (99.57%) on day 21, with significant reductions in mean egg counts (p 0.0001). No evidence of anthelmintic resistance was detected following WAAVP guidelines. The untreated control group showed a significant increase in egg counts, indicating active parasitic infection. These findings confirm the continued effectiveness of fenbendazole and ivermectin in controlling GIN in the region and underscore the importance of ongoing efficacy monitoring and integrated parasite management to sustain drug efficacy and prevent resistance in smallholder goat farming systems.